Barcelona will host Real Madrid on October 24 in LaLiga.
It will be the first El Clasico in the league since the departure of Lionel Messi and Sergio Ramos.
The match is set to kick off at 10:15 am ET (7:15 am PT).
Barca has struggled this season without Messi, who has since signed for PSG as a free agent.
Manager Ronald Koeman is under intense pressure following a string of poor results.
Madrid, who are now coached by Carlo Ancelotti, have started the season strongly.
Los Blancos currently top the table with 16 points, two more than rivals Atletico.
Barcelona’s last win at home over Madrid came in October 2018.
Barcelona vs Real Madrid Clasico dates confirmed as LaLiga announces 2021/22 fixtures